A thrombin-cross-reactive anticardiolipin antibody binds to and inhibits the anticoagulant function of activated protein C

C-reactive protein binds to alphaIIbbeta3.

Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme.

Human protein C was purified. and the mechanism of action of activated protein C as an anticoagulant in plasma was studied. Protein C was purified from commercial factor IX concentrate by DEAE-Sephadex and dextran sulfate-Sepharose chromatography and preparative polyacrylamide gel electrophoresis. Purified protein C appeared homogenous at 62.000 mol wt on nonreduced SDS-polyacrylamide gels and....

Alpha-2-macroglobulin inhibits the anticoagulant action of activated protein C in cord and adult plasma.

Healthy newborns have a very low risk of thrombosis. It has been suggested that this is partly due to the anticoagulant effect of alpha-2-macroglobulin (a2-M). This broad-spectrum protease binding glycoprotein is physiologically elevated in newborns over adult values and has been shown to complex generated alpha-thrombin. In our present study, we point out that a2-M also acts as a procoagulant ...

a synchronic and diachronic approach to the change route of address terms in the two recent centuries of persian language

terms of address as an important linguistics items provide valuable information about the interlocutors, their relationship and their circumstances. this study was done to investigate the change route of persian address terms in the two recent centuries including three historical periods of qajar, pahlavi and after the islamic revolution. data were extracted from a corpus consisting 24 novels w...

Mac-1 Directly Binds to the Endothelial Protein C-Receptor: A Link between the Protein C Anticoagulant Pathway and Inflammation?

OBJECTIVE The endothelial protein C-receptor (EPCR) is an endothelial transmembrane protein that binds protein C and activated protein C (APC) with equal affinity, thereby facilitating APC formation. APC has anticoagulant, antiapoptotic and antiinflammatory properties. Soluble EPCR, released by the endothelium, may bind activated neutrophils, thereby modulating cell adhesion. EPCR is therefore ...